Perifosine is an oral anti-cancer drug that inhibits the ability of the cells to use the protein kinase Akt. Akt is used at the cellular level to help with metabolism, the death of cells, and the proliferation of cells. Perifosine has been given Orphan Drug Status to treat multiple Myeloma blood cancer. It is currently in phase 3 clinical trials for the treatment of this type of blood cancer.
There is hope for the treatment of Mesothelioma, as well. Perifosine has been shown to inhibit the EGFR/MET-AKT1/3 axis, which could prove useful in the treatment of Mesothelioma.
The asbestos linked cancer, Mesothelioma, is an extremely aggressive disease that attacks the mesothelium, which is the membrane sack that surrounds almost all human organs. Approximately 2500 new cases of Mesothelioma are diagnosed in the United States each and every year.
A recent study published in Plos One, an online medical journal, explained that studies have been performed using Perifosine to treat Mesothelioma and it has been effective in interfering with the cancer cell membranes, and in turn, halting their growth and development. When a combination of Perifosine and Cisplatin (a chemotherapy drug) was used, the results were even more pronounced.
Since Mesothelioma is one of the most aggressive types of cancer, finding a treatment option that actually halts the development of the cancer cells could be a great option for patients with this disease. This might actually give physicians the opportunity to remove or treat the cells already present if the constant spreading of the disease could be slowed or stopped.
There are many treatment combinations for Mesothelioma. The best treatment options vary from patient to patient depending on the stage of the cancer and the strength of the patients immune system. Perifosine might very well be an excellent option to use in combination with other treatments to stop the malignancy of the cancer and treat the cancer cells that already exist.
Each patient needs to work closely with physicians and specialists to ensure the best treatment plan possible for the stage of the disease. Since Mesothelioma is an aggressive form of cancer, treatments may need to be decided quickly to help stop the progression of the cancer. Perifosine may be able to help slow the progression of the cancer, thus giving patients more of a chance to consider all of the treatment options before deciding on one. Every patient and every situation is different, thus the best treatment option should be tailored to meet the needs of the patient.